Current Issue : January-March Volume : 2025 Issue Number : 1 Articles : 5 Articles
The current research is focused on the discovery and optimization of an effective cosmetic carrier of alpha-bisabolol as a first step in the development of a cosmetic product with cleansing and antimicrobial action for facial skin hygiene. A micellar solution of Poloxamer 407 was selected as a cosmetic base because of the good washing ability, easy application, and high tolerability of this polymeric surfactant. The solubilization capacity of a 5% micellar solution with respect to α-bisabolol was investigated by applying varying solubilization techniques and increasing concentrations of the oily active substance. The test samples were subjected to an accelerated physical stability test, viscosimetry, dynamic light scattering (DLS), electrophoretic light scattering (ELS), foamability test, and antimicrobial screening. Over the course of this research, the advantage of the film-hydration method over direct solubilization was demonstrated by the narrower size distribution and smaller hydrodynamic size of the micellar nano-carriers (ranging from 29.02 to 116.5 nm) and the respective higher physical stability of the dispersions. The optimized composition was found to be suitable for application on large skin areas in terms of viscosity in the temperature range from 20 ◦C to 40 ◦C (3.4–2.3 mPa.s). Preservation of the washing capacity of the micellar solution in the presence of solubilized α-bisabolol was established. The active composition demonstrated inhibitory activity against Staphylococcus aureus and Escherichia coli and fungicidal activity against Candida albicans. This study concludes that the optimal concentration of α-bisabolol to be solubilized in a 5% Poloxamer 407 micellar solution by the film-hydration technique is 1%, considering the desirable physical endurance and antimicrobial activity....
Palmyra palm is a resourceful plant species that can be put to use in superabundance. Its extensive range of use stretches in all directions—making it useful for consumption in countless forms, and the cosmetic industry is not a deviation from this. In accordance with the beneficial molecules generated in it, such as polyphenols, flavonoids, carotenoids and others, the addition of Palmyra raises incentives like reduction and microbe prevention when developed into therapeutic products. Therefore, the virtues of Palmyra fruit, sap, leaves, pulp, bark, haustoria and other parts are being diversely exploited in the beauty and health industry at present. To summarise the compass of Palmyra palm and its products in cosmetology and dermatology, an overview is drafted exploring the extant literature on the topic. Following the description of the available molecules, their adoption into skincare products and in vivo effects was analysed in this study. Aiming to highlight the prospects of Palmyra in skin and personal care formulations, this article discusses the span of its potential in light of its physicochemical attributes....
Seaweed is a great source of biologically active metabolites which could prove interesting in cosmeceutical applications. In this study, seven Icelandic seaweed species (Ascophyllum nodosum, Alaria esculenta, Laminaria hyperborea, Laminaria digitata, Saccharina latissima, Palmaria palmata, and Schizymenia jonssonii) were screened for total polyphenol content, antioxidant properties, and inhibition of skin-degrading enzymes. Antioxidant assays included DPPH (2,2-diphenyl-1-picrylhydrazyl), reducing power, and ORAC (oxygen radical absorbance capacity). In most assays, A. nodosum extracts were the most active. A. nodosum extracts also showed the strongest inhibition of the skin-degrading enzymes elastase and collagenase at low concentrations, demonstrating its skin-protective qualities. To further investigate the activity, A. nodosum was subsequently extracted with solvents with increasing polarity into seven different extracts. Compared to other extracts, the extracts obtained by extraction with acetone and methanol showed the highest activity in all assays. Extracts obtained with room-temperature water and 85 ◦C water also demonstrated moderate to high activities. The outcomes of this study support the potential utilization of the brown seaweed A. nodosum as a source of natural ingredients in cosmeceuticals....
Resveratrol has been found to stimulate the growth of human dermal papilla cells (hDPCs) and protect them from oxidative damage. The topical application of resveratrol effectively enhanced hair growth and stimulated the transition of the hair cycle from the resting phase (telogen) into the active growth phase (anagen phase). The aim of this study was to examine the effects of resveratrolrich peanut callus and sprout extracts on promoting hair growth and anti-hair loss effects in hDPCs and then select the most effective extract (callus) for further assessment in clinical applications. The peanut sprout and callus were produced from plant seeds and extracted with ethanol. Resveratrol was identified as the major constituent in the extracts obtained using the HPLC approach, although no resveratrol was found in the original seed extract. Hair cell proliferation, growth factor expression, and 5α-reductase (5-AR) inhibition assays were used to examine the extracts’ promotion of hair growth and inhibition of anti-hair loss in an in vitro hDPCs model, and standard resveratrol served as a positive reference. Initially, the cytotoxicity of the samples was assessed, revealing that 2.5% of all extracts and 0.02% of resveratrol exhibited a non-cytotoxic effect to hDPCs. The 50% cytotoxic concentration of peanut callus extract (15.50 ± 0.05%) was significantly less cytotoxic to hDPCs than sprout (12.30 ± 0.14%) and seed (11.69 ± 0.26%) extracts (p < 0.05). In vitro experiments indicated that peanut callus extract had the greatest proliferated hDPCs (20.44 ± 0.78%), increased the expression of growth factors (IGF-1, KGF, and HGF) and inhibited 5AR (27.83 ± 2.48%). Then, the callus extract and resveratrol as the positive standard were separately incorporated into a hair serum base and assessed for anti-hair loss effect in a randomized, double-blind, placebo-controlled clinical trial on 60 subjects, and the daily hair shedding count, one-minute combing, and forcible hair pluck tests were monitored for 12 weeks. The clinical study showed that the hair serum containing peanut callus extract and resveratrol were effective in reducing hair shedding (66.98% and 61.47%), decreased hair fall from combing by (83.92% and 68.19%), and increased the ratio of the anagen/telogen by (3.3 and 2.8, respectively). The results suggest that peanut callus extract has a significant amount of resveratrol and the potential to stimulate hair growth and prevent hair loss, making it an alternative bioactive option for cosmetic applications....
Oxidative stress is a primary contributor to human skin aging, while antioxidants are known to mitigate skin damage related to aging processes. In this study, we investigated the possible action of trifluoromethyl phenethyl mesalazine (TFM), an antioxidizing agent, on skin aging processes, including skin wrinkles and pigmentation. Our data revealed that TFM exerted a strong free radical scavenging capability and notably inhibited melanin production. Moreover, TFM downregulated the UV-induced production of matrix metalloproteinase-1 and interleukin-6 in cultured human skin fibroblasts. Furthermore, in a clinical study with 24 women, TFM significantly reduced skin wrinkles and improved skin brightness compared to a placebo. These findings highlight the previously unrecognized effects of TFM on skin health by mitigating skin aging processes associated with oxidative damage....
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